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PMPI(Protein Crosslinker heterobifunctional) CL223 N-(p-Maleimidophenyl)isocyanatef.w.: 214.2 daltons |
PMPI is a maleimide-and-isocyanate crosslinker for attaching compounds to sulfhydryl groups (cysteines) after conjugating the linker to hydroxyl groups on a molecule by urethane (carbamate) bonds
| Quantity | Price | |
|---|---|---|
| 50mgm + | $176.00 |  |
| 100mgm + | $333.00 | |
| Download***Certificate of Analysis*** | ||
Spacer arm 8.7 angstroms. Heterobifunctional crosslinker. Novel sulfhydryl and hydroxyl reactive crosslinker. Non-cleavable. Excellent tool for the preparation of conjugates of hydroxyl containing compounds such as steriods and vitamins.
- Annunziato, M.E., Patel, U.S., Ranade, M. and Palumbo, P.S. (1993). p-Maleimidophenyl isocyanate: A novel heterobifunctional linker for hydroxyl to thiol coupling. Bioconjugate Chem. 4, 212-218.
- Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
- Isocyanate reacts with OH groups to form a carbamate link at pH 8.5
- Excellent tool for conjugating OH group-containing compounds such as steroids and vitamins
- Novel sulfhydryl- and hydroxyl-reactive heterobifunctional crosslinker
- Non-cleavable
- Reactive groups: maleimide and isocynate
- Reactive toward: sulfhydryl and hydroxyl groups