MTBSTFA + 1% t-BuDMClSi N-(t-Butyldimethylsilyl)-N-methyltrifluoroacetamide + 1% t-Butyldimethylchlorosilane

MTBSTFA is a Silylation Reagent for GC Derivatization that replaces active hydrogens to form t-BDMS derivatives. Derivatization is usually complete upon dissolution with this exceptionally strong, yet mild silylating reagent. MTBSTFA derivatives are 104 times more stable to hydrolysis than their corresponding TMS derivatives and produces easily interpreted mass spectra for GC/MS. Addition of t-BDMCS catalyzes reactions of hindered alcohols and amines.