SATA N-Succinimidyl-S-acetylthioacetate
| Catalog # | M101 |
|---|---|
| CAS Number | 76931-93-6 |
| Molecular Formula | C8H9NO5S |
| Formula Weight | f.w.: 231.2 daltons |
SATA is a short chain (2.8 angstrom spacer arm) reagent for covalent modification of primary amines and the addition of a protected yet exposable sulfhydryl group, enabling heterobifunctional crosslinking strategies.
Pricing & Ordering
| Quantity | Price | Action |
|---|---|---|
| 1gm | $630.00 |
|
| 2.5gm + | $1,617.00 |
|
| 50mgm + | $71.00 |
|
| 100mgm + | $133.00 |
|
| 500mgm + | $568.00 |
|
Product Documents
Spacer arm 2.8 angstroms.Protein modification reagent. Used to introduce protected thiol groups onto primary amines. The protected sulfhydryl prevents dipeptide formation. When treated with hydroxylamine a free sulfhydyl group can then be conjugated to maleimide modified protein. Purity >96% by HPLC. Soluble in DMSO and methylene chloride.
1. Duncan, R.J.S., et al. (1983). A new reagent which may be used to introduce sulfhydryl groups into proteins, and its use in the preparation of conjugates for immunoassay. Anal Biochem 132: 68-73.
- SATA adds a protected sulfhydryl that can be deprotected by hydroxylamine
- Allows long-term storage of the sulfhydryl-modified molecule
- Forms cleavable disulfide bonds with other sulfhydryl-containing molecules
- SATA reacts with primary amines (lysine residues and the amino terminus of a protein) to form stable amide bonds
- Preserves protein activity with its mild, non-denaturing reaction conditions
Articles about SATA
Protein Modifier Buyer's Guide for Research Workflows
A practical overview of the Protein Modifier category, including what these reagents are, where they fit in research workflows, and how to compare supplied…