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DSS(Protein Crosslinker homobifunctional) CL100 Disuccinimidylsuberate[ 68528-80-3 ] f.w.: 368.3 daltons |
DSS is a non cleavable and membrane permeable crosslinker that contains an amine reactive N-hydroxysuccinimide (NHS) ester at each end of an 8-carbon spacer arm.
| Quantity | Price | |
|---|---|---|
| 2gm + | $212.00 |  |
| 5gm + | $529.00 | |
| 10gm + | $1000.00 | |
| Download***Certificate of Analysis*** | ||
Spacer arm 11.4 angstroms. Homobifunctional reagent. Noncleaveable amine reactive homobifunctional crosslinker. Has been used for conjugating radiolabeled ligand to cell surface receptor. Purity >95% by HPLC.
- Chataway, T.K. and Barritt, G.J. (1995). Mol. Cell. Biochem. 145(2), 111-120.
- Donato, R., et al. (1989). J. Neurochem. 53(2), 566-571.
- Ishmael, F.T., et al. (2005) Intersubunit and Domain Interactions of the Meprin B Metalloproteinase: Disulfide Bonds and Protein-Protein Interactions in the MAM and TRAF Domains. J. Biol. Chem.280, 13895-13901.
- Longshaw, V.M., et al. (2004) Nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases. J. Cell Sci. 117, 701-710.
- Mattson, G., et al. (1993). A practical approach to crosslinking. Molecular Biology Reports 17, 167-183.
- Mathieu, M., et al. (1990). Mol. Endocrinol. 4(9), 1327-1335.
- Partis, M.D., et al. (1983). Crosslinking of proteins by omega-maleimido alkanoyl N-hydroxysuccinimide esters. J. Protein. Chem. 2, 263-277.
- Amine reactive Sulfo NHS ester reacts rapidly with any primary amine containing molecule
- DSS crosslinker is membrane permeable, so intracellular crosslinking can be done
- High purity, crystalline DSS can be used to create high-purity conjugates