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SULFO SMCC(Protein Crosslinker heterobifunctional) CL207 Sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate[ 92921-24-9 ] f.w.: 436.4 daltons |
Sulfo SMCC is a very useful,water soluble, amine to sulfhydryl reactive crosslinker that contains NHS ester and maleimide reactive groups at opposite ends of a medium length cyclohexane spacer arm (8.3 angstroms).
| Quantity | Price | |
|---|---|---|
| 50mgm + | $143.00 |  |
| 100mgm + | $270.00 | |
| Download***Certificate of Analysis*** | ||
- Ideal crosslinker for enzyme labeling of antibodies, both enzyme activity and antibody specificity can be preserved
- Create specific bioconjugates via one- or two-step crosslinking reactions
- Create sulfhydryl-reactive, maleimide-activated carrier proteins for coupling haptens
- Muller L. et al. (2010) Evolutionary gain of function for the ER membrane protein Sec62 from yeast to humans. Mol. Biol. Cell. 21, 691-703.
- Dickgreber N. et al. (2009) Targeting antigen to MHC class II molecules promotes efficient cross-presentation and enhances immunotherapy. J. Immunol. 182, 1260-9.
- Kersemans V. et al. (2008) Drug-resistant aml cells and primary aml specimens are killed by 111In-anti-CD33 monoclonal antibodies modified with nuclear localizing peptide sequences. J. Nucl. Med. 49, 1546-54.
- Duval M. et al. (2008) A bispecific antibody composed of a nonneutralizing antibody to the gp41 immunodominant region and an anti-CD89 antibody directs broad human immunodeficiency virus destruction by neutrophils. J. Virol. 82, 4671-4.
- Costantini D. L. et al. (2008) Trastuzumab-resistant breast cancer cells remain sensitive to the auger electron-emitting radiotherapeutic agent 111In-NLS-Trastuzumab and are radiosensitized by methotrexate. J. Nucl. Med. 49, 1498-505.
- Brinkmann M. M. et al. (2007) The interaction between the ER membrane protein UNC93b and TLR3, 7, and 9 is crucial for TLR signaling. J. Cell Biol. 177, 265-75.
- Kehoe J. W. et al. (2006) Using phage display to select antibodies recognizing post-translational modifications independently of sequence context. Mol. Cell. Proteomics. 5, 2350-63.
- Amine reactive Sulfo NHS ester crosslinks rapidly with primary amine-containing molecule
- Sulfhydryl-reactive maleimide reacts with cysteine residues to yield specific conjugates
- Sulfo SMCC is water soluble, so crosslinking can be done in physiologic solutions
- High purity, crystalline Sulfo-SMCC can be used to create high-purity maleimide-activated derivatives
- Cyclohexane bridge confers added stability to the maleimide group making Sulfo SMCC the ideal crosslinking agent for maleimide activation of proteins.