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KMUH(Protein Crosslinker heterobifunctional) CL224 N-(kappa-Maleimidoundecanoic acid) hydrazidef.w.: 295.4 daltons |
KMUH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).
| Quantity | Price | |
|---|---|---|
| 50mgm + | $103.50 |  |
| 100mgm + | $195.50 | |
Spacer arm 19.0 angstroms. Heterobifunctional crosslinker. Sulfhydryl reactive and carbonyl reactive. Long non-cleavable aliphatic spacer arm. Hydrazide group covalently couples to oxidized carbohydrate residues in glycoproteins and other glycoconjugates.
1. Trail, P.A., et al. (1993). Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science 261, 212-215.
- Sulfhydryl-reactive and carbonyl-reactive heterobifunctional crosslinking agent
- Long, non-cleavable, aliphatic cross-bridge
- Hydrazide group covalently couples to oxidized carbohydrate residues in glycoproteins and other glycoconjugates
- Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
- Reactive groups: maleimide and hydrazide
- Reactive toward: sulfhydryl and carbonyl (aldehyde)/carboxyl groups