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(Protein Crosslinker heterobifunctional)

CL202   3-Maleimidobenzoyl-N-hydroxysuccinimide ester
[ 58626-38-3 ]   f.w.: 314.2 daltons

MBS is an amine to sulfhydryl crosslinker that contains NHS ester and maleimide reactive groups at opposite ends of a short aromatic spacer arm (7.3 angstroms).

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50mgm + $72.00
100mgm + $137.00
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Spacer arm 9.9 angstroms. Heterobifunctional crosslinker. A crosslinker that is useful for conjugation of enzymes to antibodies, haptens to carrier proteins and toxins to antibodies. Purity > 95% by TLC. Soluble in DMSO and chloroform.

  1. Chrisey, L.A., et al. (1996). Nucleic Acids Res. 24(15), 3031-3039. 
  2. Myers, D.E., Uckun, F.M., Swaim, S.E. and Vallera, D.A. (1989). The effects of aromatic and aliphatic maleimide crosslinkers and anti-CD-5 ricin immunotoxins. J. Immunol. Meth. 121, 129-142. (MBS example) 
  3. Kitagawa, T. and Aikawa, T. (1976). Enzyme coupled immunoassay of insulin using a novel coupling reagent. J. Biochem. (Tokyo) 79, 233-236.

•Water insoluble •Non-cleavable •Popular for forming enzyme immunoconjugates •Reactive groups: NHS ester and maleimide •Reactive towards: amino and sulfhydryl groups