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NDSB 256 4T(NDSB Reagents) NDSB2564T 3-(4-tert-Butyl-1-pyridino)-1-propane sulfonate[ 570412-84-5 ] 257.35 |
NDSB 256 4T is a non-detergent sulfobetaine ( NDSB ) that prevents protein aggregation and facilitates protein folding by interacting with the early folding intermediates. Reported to improve the in vitro renaturation efficiency of reduced hen egg lysozyme (60% enzymatic activity at 600 mM ( NDSB-256-4T ) and chemically unfolded tryptophan synthase β2 subunit (100% enzymatic activity at 1 M( NDSB-256-4T ).
Expert-Bezancon, N., et. al., Biophys Chem, 100, 469 (2003).