SATA
(Protein Modifier)
M101
N-Succinimidyl-S-acetylthioacetate
CAS#: [ 76931-93-6 ]
Formula Weight: f.w.: 231.2 daltons
SATA is a short chain (2.8 angstrom spacer arm) reagent for covalent modification of primary amines and the addition of a protected yet exposable sulfhydryl group, enabling heterobifunctional crosslinking strategies.
Pricing & Ordering
| Quantity | Price | Action |
|---|---|---|
| 1gm | $630.00 | |
| 2.5gm + | $1,617.00 | |
| 50mgm + | $71.00 | |
| 100mgm + | $133.00 | |
| 500mgm + | $568.00 |
Product Documents
Spacer arm 2.8 angstroms.Protein modification reagent. Used to introduce protected thiol groups onto primary amines. The protected sulfhydryl prevents dipeptide formation. When treated with hydroxylamine a free sulfhydyl group can then be conjugated to maleimide modified protein. Purity >96% by HPLC. Soluble in DMSO and methylene chloride.
1. Duncan, R.J.S., et al. (1983). A new reagent which may be used to introduce sulfhydryl groups into proteins, and its use in the preparation of conjugates for immunoassay. Anal Biochem 132: 68-73.
- SATA adds a protected sulfhydryl that can be deprotected by hydroxylamine
- Allows long-term storage of the sulfhydryl-modified molecule
- Forms cleavable disulfide bonds with other sulfhydryl-containing molecules
- SATA reacts with primary amines (lysine residues and the amino terminus of a protein) to form stable amide bonds
- Preserves protein activity with its mild, non-denaturing reaction conditions