BSTFA + 1% TMCS (GC Diagnostic Reagent silylation) GC114   Bis(trimethylsilyltrifluoroacetamide) + 1% Trichloromethylsilane [ 247-103-9 ]

BSTFA is a Silylation Reagent for GC Derivatization that reacts faster and more completely than BSA, due to the trifluoroacetamide leaving group.  The high volatility of BSTFA and its byproducts results in non-co-elution of early eluting peaks.  Additionally, the highly volatile and stable products result in low detector noise and fouling.

Addition of TMCS to BSTFA catalyzes reactions of hindered functional groups and other difficult functionalities, such as secondary hydroxyls and amines.